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Patented imaging software that measures your liver health.


Liver Nodularity was launched in Mississippi on March 5, 2014. The company was a spin-off related to innovative technology created by Andrew D. Smith, M.D. Ph.D., the president and founder. The company transferred to Alabama in 2017, when Smith took the job of vice chair of Clinical Research in the Department of Radiology at the University of Alabama at Birmingham.

Liver Nodularity developed the software in collaboration with commercial software engineers who were paid fee-for-service using grant funds. Liver Nodularity has patents pending in the U.S. and European Union and patent claims accepted in Japan.

Smith works with funded and volunteer researchers at UAB to extensively validate the technology for multiple potential uses. He is currently running a multi-institutional study with Cleveland Clinic, Duke, Emory, UAB, UCSD, and the University of Wisconsin. Furthermore, Smith has distributed the technology to 10 luminary sites (academic medical centers) for external validation of the technology.

Liver Nodularity is a part of the UAB Commercialization Accelerator and has partnered with Imaging Biometrics (Elm Grove, WI) as the commercial software developers who will also assist with FDA 510(k) and CE clearance. We are currently engineering a commercial version of the Liver Surface Nodularity (LSN) Software and preparing application for FDA 510(k) clearance in the U.S. and CE clearance in the European Union. We are also seeking funding to develop the sales and marketing team to take this product to market.


Our president and founder is Andrew D. Smith, M.D. Ph.D., a physician scientist who is a practicing academic radiologist, an inventor, and an entrepreneur. Smith is the vice chair of Clinical Research in Radiology, director of the Human Imaging Shared Facility, and a practicing abdominal radiologist at the University of Alabama at Birmingham (UAB). He is also a founding member and the chair of the UAB Physician Innovation Network.

He has multiple U.S. and international patents received and pending related to advancements in radiology and is the founder of several start-up companies including Liver Nodularity, Color Enhanced Detection, Radiostics and eRadioMetrics.

He has been the primary investigator on multiple grants, including NIH small business grants and industry-sponsored grants. Smith has run multiple retrospective and prospective clinical studies, including several multi-institutional studies, and he has mentored numerous students, residents, fellows, and research scientists and faculty.

On a national level, Smith is a Fellow of the Society of Abdominal Radiology (SAR), Fellow of the Society of Computed Body Tomography and Magnetic Resonance (SCBT-MR); and member of the Radiological Society of North America (RSNA), American Roentgen Ray Society (ARRS), American Society of Clinical Oncology (ASCO), American College of Radiology (ACR), Association of University Radiologists (AUR), ECOG-ACRIN, and SWOG.


Smith has served on the SAR research committee, SAR Disease-Focused Panel on Hepatic Fibrosis, SAR Disease-Focused Panel on Renal Cell Carcinoma, SCBT-MR research committee, RSNA GI research committee, ECOG-ACRIN GU Committee, SWOG GU Committee, ACR Appropriateness Criteria in GU Imaging, ACR Data Science Institute, ACR Artificial Intelligence Use Case Panel for Abdominal Imaging, and AUR Radiology Research Alliance. He is a co-chair of the SAR Emerging Technology Commission, with an emphasis on Artificial Intelligence and Machine Learning.

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